Transformations of Griseofulvin in Strong Acidic Conditions – Crystal Structures of 2′-Demethylgriseofulvin and Dimerized Griseofulvin

Cardiovascular effects of griseofulvin.

The intravenous administration of griseofulvin in doses of 3.0 mg/kg to 32 anesthetized open-chest dogs produced marked increments (43%) in isometric systolic force measured by a strain gauge. These changes were accompanied by an increase (22%) in heart rate and a decrease (25%) in blood pressure. The effect was unaltered by clamping the blood supply to and from the adrenal glands or by previou...

The chemistry of griseofulvin.

Ketoconazole in griseofulvin-resistant dermatophytosis.

The efficacy of ketoconazole was evaluated in twenty patients with chronic dermatophyte infections who had failed to clear with griseofulvin therapy. Trichophyton rubrum was the causative organism in nineteen of the patients, and Trichophyton mentagrophytes in one patient. Three of twelve organisms tested showed in vitro resistance to griseofulvin. Duration of infection ranged from 2 to 28 year...

Effects of griseofulvin in experimental rabbit syphilis.

We have previously reported the effects of some antibiotics on experimental rabbit syphilis (Fujita, Asada, and Amawashi, 1962). The recent resurgence of infectious syphilis has led us to look for more effective anti-luetic agents. From this point of view we are studying the ultrastructure of spirochaetes (Hasegawa, Sasahira, and Matsuura, 1965; Hasegawa and Sasahira, 1965; Hasegawa, Komura, an...

Raynaud's disease treated with griseofulvin.

The patient, a 7-year-old girl, with no previous history of circulatory disorder, developed rubella, and a week later a discoloration of her fingers was noted. The index finger of the right hand became purple and cold and then the index finger of her left hand became similarly affected. Other fingers were soon involved (see Fig.) and by the third week some discoloration of the toes was noticed....